Bob Newhart

Bernard (voice)

Eva Gabor

Miss Bianca (voice)

John Candy

Wilbur (voice)

Tristan Rogers

Jake (voice)

Adam Ryen

Cody (voice)

George C. Scott

McLeach (voice)

Wayne Robson

Frank (voice)

Douglas Seale

Krebbs (voice)

Frank Welker

Joanna (voice)

Bernard Fox

Chairman / Doctor (voice)

Peter Firth

Red (voice)

Ed Gilbert

Francois (voice)

Carla Meyer

Faloo / Mother (voice)

Russi Taylor

Nurse Mouse (voice)

Peter Greenwood

Radio Announcer / Airplane Captain (voice)

Billy Barty

Baitmouse (voice)

Mickie McGowan

International Mice (voice) (uncredited)

Jack Angel

Additional Voices (voice)