Eddie Murphy

Dr. John Dolittle

Ossie Davis

Archer Dolittle

Oliver Platt

Dr. Mark Weller

Peter Boyle

Calloway

Richard Schiff

Dr. Gene Reiss

Kristen Wilson

Lisa

Jeffrey Tambor

Dr. Fish

Kyla Pratt

Maya

Raven-Symoné

Charisse

Steven Gilborn

Dr. Litvack

Erik Dellums

Jeremy

June Christopher

Diane

Cherie Franklin

Mrs. Parkus

Mark Adair-Rios

Intern

Don Calfa

Patient at Hammersmith

Arnold F. Turner

Animal Control Officer

Kay Yamamoto

Receptionist

Kellye Nakahara

Beagle Woman

Beth Grant

Woman

Yule Caise

Vet's Assistant

Brian Kwan

Busboy

L. Peter Callender

Policeman

Charles Branklyn

Security Guard

Cliff McLaughlin

Mounted Policeman

Richard Penn

Mr. Galvin

John Lafayette

Reverend

Raymond Matthew Mason

3-Year-Old John Dolittle

Dari Gerard Smith

5-Year-Old John Dolittle

Karl T. Wright

Reporter

Stan Sellers

Cop #1

Ming Lo

Cop #2

Norm Macdonald

Lucky (voice)

Albert Brooks

Tiger (voice)

Chris Rock

Rodney (voice)

Reni Santoni

Rat #1 (Voice)

John Leguizamo

Rat #2 (Voice)

Julie Kavner

Female Pigeon (voice)

Garry Shandling

Male Pigeon (voice)

Ellen DeGeneres

Prologue Dog (voice)

Brian Doyle-Murray

Old Beagle (voice)

Phil Proctor

Drunk Monkey (Voice)

Jenna Elfman

Owl (Voice)

Gilbert Gottfried

Compulsive Dog (Voice)

Phyllis Katz

Goat (voice)

Douglas Shamburger

Pound Dog (voice)

Jeff Doucette

Possum (voice)

Archie Hahn

Heavy Woman's Dog (voice)

Tom Towles

German Shepherd (voice)

Eddie Frierson

Skunk (voice)

Paul Reubens

Raccoon (voice)

Kerrigan Mahan

Penguin (voice)

Royce D. Applegate

'I Love You' Dog (voice)

James F. Dean

Orangutan (voice)

Chad Einbinder

Bettleheim the Cat (voice)

Jonathan Lipnicki

Baby Tiger (voice)

Hamilton Camp

Pig (voice)

Kerrigan Mahan

Penguin (voice)

Crystal the Monkey

Drunk Monkey (uncredited)

Benny Buettner

Circus Clown (uncredited)

Bebe Conrad

Circus Clown (uncredited)

Paul Giamatti

Blaine (uncredited)

Kellan Patrick

Jumping Boy (uncredited)

Pruitt Taylor Vince

Patient at Hammersmith (uncredited)