Johnny Depp

Rango / Lars (voice)

Isla Fisher

Beans (voice)

Ned Beatty

Mayor (voice)

Bill Nighy

Rattlesnake Jake (voice)

Alfred Molina

Roadkill (voice)

Abigail Breslin

Priscilla (voice)

Claudia Black

Angelique (voice)

Ray Winstone

Bad Bill (voice)

Timothy Olyphant

Spirit of the West (voice)

Stephen Root

Doc / Merrimack / Mr. Snuggles (voice)

Harry Dean Stanton

Balthazar (voice)

Ian Abercrombie

Ambrose (voice)

Gil Birmingham

Wounded Bird (voice)

James Ward Byrkit

Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice)

Blake Clark

Buford (voice)

Keith Campbell

Sod Buster (voice)

Beth Grant

Bonnie (voice)

John Cothran

Elgin (voice)

George DelHoyo

Señor Flan - Mariachi Accordion (voice)

Patrika Darbo

Delilah / Maybelle (voice)

Maile Flanagan

Lucky (voice)

Charles Fleischer

Elbows (voice)

Ryan Hurst

Jedidiah (voice)

Vincent Kartheiser

Ezekiel / Lasso Rodent (voice)

Hemky Madera

Chorizo (voice)

Alex Manugian

Spoons (voice)

Mark 'Crash' McCreery

Parsons (voice)

Joe Nuñez

Rock-Eye (voice)

Christopher Lee Parson

Hazel / Kinski / Stump / Clinker / Lenny / Boseefus (voice)

Christopher L. Parson

Hazel Moats / Kinski / Stump / Clinker / Lenny / Boseefus /Dirt Kid (voice)

Lew Temple

Furgus / Hitch (voice)

Alanna Ubach

Boo / Cletus / Fresca / Miss Daisy (voice)

Gore Verbinski

Sgt Turley / Crevice / Slim / Lupe - Mariachi Violin (voice)

Kym Whitley

Melonee (voice)