Nathan Lane

Spot Helperman / Scott Leadready II / Scott Manly-Manning (voice)

Kelsey Grammer

Dr. Ivan Krank (voice)

Shaun Fleming

Leonard Amadeus Helperman (voice)

Debra Jo Rupp

Mrs. Mary Lou Moira Angela Darling Helperman (voice)

David Ogden Stiers

Mr. Jolly (voice)

Jerry Stiller

Pretty Boy (voice)

Paul Reubens

Dennis (voice)

Megan Mullally

Adele (voice)

Wallace Shawn

Principal Crosby Strickler (voice)

Jay Thomas

Barry Anger (voice)

Estelle Harris

Mrs. Boogin (voice)

Rosalyn Landor

The Blue Fairy (voice)

Rob Paulsen

Ian Wazselewski (voice)

Genie Ann Francis

Marsha / Marcia (voice)

Anthony Gearing

John / Juan (voice)

Mae Whitman

Leslie Dunkling (voice)

Lauren Tom

Younghee (voice)

Pamela Adlon

Trevor / Taylor / Tyler (voice)

Timothy Stack

Father (voice)

Emma Steinkellner

Little Girl (voice)

Ken Swofford

Officer White (voice)

Kevin Michael Richardson

Conductor (voice)

Anthony Geary

John / Juan

Genie Francis

Marsha / Marcia