Reign: The Conqueror (1999)

Original title: アレクサンダー戦記

In the 4th century B.C., a pagan shaman prophesies that Olympias, Queen of Macedonia, wife of King Phillip II will give birth to a baby who will grow up to destroy the world, and the baby named Alexander. Years later, Alexander with many successful campaigns unifies Persia and Macedonia, so great that it makes Aristotle worry that the world can be destroyed by Alexander's advance toward the East...