Jared Leto

Harry Goldfarb

Ellen Burstyn

Sara Goldfarb

Jennifer Connelly

Marion Silver

Marlon Wayans

Tyrone C. Love

Christopher McDonald

Tappy Tibbons

Keith David

Big Tim

Louise Lasser

Ada

Marcia Jean Kurtz

Rae

Janet Sarno

Mrs. Pearlman

Suzanne Shepherd

Mrs. Scarlini

Joanne Gordon

Mrs. Ovadia

Charlotte Aronofsky

Mrs. Miles

Mark Margolis

Mr. Rabinowitz

Michael Kaycheck

Donut Cop

Peter Maloney

Dr. Pill

Denise Dowse

Tyrone's Mother

Olga Merediz

Malin & Block Secretary

Ben Shenkman

Dr. Spencer

Dylan Baker

Southern Doctor

Bill Buell

Court Doctor

Lianna Pai

Angelic Nurse

Stanley B. Herman

Uncle Hank

Gregg Bello

E.R. Doctor

Shaun O'Hagan

Ward Attendant Seto

Jimmie Ray Weeks

Prison Guard

Jack O'Connell

Corn Dog Stand Boss

Scott Franklin

Jailer (voice)

Chas Mastin

Lyle Russel

Ajay Naidu

Mailman

Sean Gullette

Arnold the Shrink

Samia Shoaib

Nurse Mall

Abraham Abraham

King Neptune

Aliya Campbell

Alice

Te'ron A. O'Neal

Young Tyrone

Bryan Chattoo

Brody

Eddie De Harp

Brody's Henchman Victor

Peter Cheyenne

Sal the Geep

Brian Costello

First AD

Abraham Aronofsky

Newspaper Man on Train

James Chinlund

Space Oddity

Allison Furman

Malin & Block Office Woman

Robert Dylan Cohen

Paramedic Greenhill

Leland Gantt

Ward Attendant Penn

Henry Stram

ECT Technician

Hubert Selby Jr.

Laughing Guard

Heather Litteer

Big Tim Party Girl

Jenny Decker

Big Tim Party Girl

Ami Goodheart

Big Tim Party Girl

Nina Zavarin

Big Tim Party Girl

Scott Bader

Party Animal

Jim Centofanti

Party Animal

Scott Chait

Party Animal

Daniel Clarin

Party Animal

Ben Cohen

Party Animal

Eric Cohen

Party Animal

Brett Feinstein

Party Animal

Ricky Fier

Party Animal

John Getz

Party Animal

Andrew Kessler

Party Animal

Ross Lombardo

Party Animal

Carter Mansbach

Party Animal

Scott Miller

Party Animal

Todd Miller

Party Animal

Joshua Pollack

Party Animal

Craig Rallo

Party Animal

Geordan Reisner

Party Animal

Keith Scandore

Party Animal

David Seltzer

Party Animal

Chris Varvaro

Party Animal

Ricardo Viñas

Party Animal

Chad Weiner

Party Animal

Jesse Weissberger

Party Animal

Greg Weissman

Party Animal

Darren Aronofsky

Visitor (uncredited)