Ryan Reynolds

Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Cable

Morena Baccarin

Vanessa

Julian Dennison

Firefist

Zazie Beetz

Domino

T.J. Miller

Weasel

Brianna Hildebrand

Negasonic Teenage Warhead

Jack Kesy

Black Tom

Shioli Kutsuna

Yukio

Stefan Kapičić

Colossus (voice)

Randal Reeder

Buck

Leslie Uggams

Blind Al

Karan Soni

Dopinder

Nikolai Witschl

Head Orderly Frye

Eddie Marsan

Headmaster

Thayr Harris

Sergei Valishnikov

Robert Maillet

Sluggo

Hayley Sales

Cable's Wife

Lewis Tan

Shatterstar

Bill Skarsgård

Zeitgeist

Terry Crews

Bedlam

Brad Pitt

Vanisher

Paul Wu

Hong Kong Boss

Alan Tudyk

Luke - Redneck #1

Rob Delaney

Peter

Michasha Armstrong

Swat Captain (School)

Joe Doserro

Bus Driver

Islie Hirvonen

Cable's Daughter

Jagua Arneja

Tree Trimmer #1

Gerry South

Tree Trimmer #2

Luke Roessler

Cereal Kid

Mike Dopud

Prison Guard

Matt Damon

Redneck #2

Andy Canete

Neighbor #1

David Leitch

Ground Chuck Mutant

Tanis Dolman

Neighbor #2

Rhett Reese

News Helicopter Pilot

Eleanor Walker

Neighbor #3

Hunter Dillon

Branding Boy

Paul Wernick

News Cameraman

Sala Baker

Older Firefist

Sonia Sunger

News Reporter (Irene)

Abiola Uthman

Chinook Pilot

Tony Bailey

Black Tom Gang Member

David Cook

Priest

Alex Kliner

Park Bench Couple

Elaine Kliner

Park Bench Couple

Valencia Budijanto

Zoo Kid

Stefania Indelicato

Bystander

Alicia Morton

Vocalist on 'Tomorrow' (voice)

Andre Tricoteux

On-Set Colossus (uncredited)

Fred Savage

Fred Savage (uncredited)

James McAvoy

Charles Xavier / Professor X (uncredited)

Nicholas Hoult

Hank McCoy / Beast (uncredited)

Evan Peters

Peter Maximoff / Quicksilver (uncredited)

Tye Sheridan

Scott Summers / Cyclops (uncredited)

Alexandra Shipp

Ororo Monroe / Storm (uncredited)

Kodi Smit-McPhee

Kurt Wagner / Nightcrawler (uncredited)

Hugh Jackman

Logan / Wolverine (archive footage) (uncredited)