Matthew McConaughey

Joseph "Coop" Cooper

Jessica Chastain

Murphy "Murph" Cooper

Anne Hathaway

Dr. Amelia Brand

Michael Caine

Professor John Brand

Casey Affleck

Tom Cooper

Ellen Burstyn

Old Murph

Mackenzie Foy

Young Murph

Bill Irwin

TARS (voice)

Wes Bentley

Doyle

David Gyasi

Romilly

John Lithgow

Donald

Matt Damon

Mann

Timothée Chalamet

Young Tom

Topher Grace

Getty

David Oyelowo

School Principal

William Devane

Williams

Josh Stewart

CASE (voice)

Collette Wolfe

Ms. Hanley

Leah Cairns

Lois

Russ Fega

Crew Chief

Lena Georgas

Nurse Practitioner

Jeff Hephner

Doctor

Elyes Gabel

Administrator

Brooke Smith

Nurse

Liam Dickinson

Coop

Francis X. McCarthy

Boots

Andrew Borba

Smith

Flora Nolan

Girl on Truck

William Patrick Brown

NASA Employee (uncredited)

Kristian Van der Heyden

Scientist (uncredited)

Mark Casimir Dyniewicz Jr.

NASA Inspector (uncredited)

Joseph Oliveira

Astronaut (uncredited)

Ryan Irving

Popcorn Seller (uncredited)

Alexander Michael Helisek

Construction Boss (uncredited)

Benjamin Hardy

NASA Scientist (uncredited)

Griffen Fraser

Boy on Truck