Kadro (21)
Ben DiskinNigel 'Numbuh 1' Uno / Hoagie Pennywhistle 'Numbuh 2' Gilligan Jr / Numbuh 101 (voice)
Lauren TomKuki 'Numbuh 3' Sanban (voice)
Dee Bradley BakerWally 'Numbuh 4' Beatles / Mr. Fibb / Toilenator / Joaquin / Tommy Gilligan (voice)
Cree SummerAbigail 'Numbuh 5' Lincoln / Former Numbuh 11 - Cree Lincoln (voice)
Jason HarrisChad Dickson (voice)
Grey DeLisleCrazy Old Cat Lady/Gramma Stuffum (voice)
Jeff BennettMr. Boss / Mr. Fizz / Benedict Wigglestein (voice)
Jennifer HaleFanny 'Numbuh 86' Fulbright / Computer (voice)
Mark HamillStickybeard (voice)
Tom KennyKnightbrace / Mr. Wink (voice)
Maurice LaMarcheFather (voice)
Matt LevinPatton 'Numbuh 60' Drilovsky (voice)
Frank WelkerMonty Uno (voice)
Neil RossGrandfather (voice)
Daran NorrisCount Spankulot (voice)
Ogie BanksSector Z Numbuh 0.1 - Bruce (voice)
Rachael MacFarlaneRachael T. 'Numbuh 362' McKenzie (voice)
Janice KawayeSonya - Number 83 / Lee - Numbuh 84 (voice)
Dave WittenbergNumbuh Zero / Lenny - Sector Z Numbuh 0.4 (voice)
Cam ClarkeAdditional Voices (voice)
Candi MiloAdditional Voices (voice)