The BAU team has a tighter than normal deadline to reach South Dakota, the last known whereabouts of Mr. Scratch. They must leave Quantico in 10 minutes. Emily Prentiss delivers the titular line for this episode: "Wheels up in 10." However, they run into trouble because the brainy supervillian has figured out how to keep the wheels of their Gulfstream jet from engaging. Will they survive a crash landing in the Badlands?

The BAU investigates three similar crimes in which victims' remains are discovered in old suitcases.

When successful businessmen in Detroit are targeted by an anger-driven power-assertive Unsub, the BAU is called in to investigate.

The BAU investigates a workplace shooting committed by a state-of-the-art drone in Silicon Valley.

Morgan lends emotional support to Garcia when she experiences anxiety over a case that is personal to her from her past.

Several women go missing in Virginia and the BAU must figure out what they all have in common in order to find them.

The BAU searches for an unsub in Austin, Texas, who is targeting prominent members of the community.

When an UnSub in Miami sensationalizes his crimes by giving the local media exclusive footage, the BAU is called in to investigate.

When two members of a conspiracy group in Roswell, N.M., perish in quick succession, the BAU is called to investigate.

When a series of backyard pool homicides are reported in California, the BAU team searches for an UnSub with a puzzling past.

The BAU team’s investigation into the home invasion and attempted homicide of a police chief’s wife uncovers a world of secrets in a small town in Virginia.

The BAU is called to New York when several casualties of a brutal nature are reported in Central Park.

The BAU is called to investigate a series of D.C. homicides where cryptic messages are found inside the mouths of each victim.

The BAU is called when the New Orleans P.D. discovers a mass grave inside a vandalized above-ground crypt in a local cemetery.

The FBI's assistant director of national security, Linda Barnes, joins the BAU as they investigate a quadruple homicide of a group of roommates in St. Louis.

Away from the watchful eye of the FBI's assistant director of national security, Linda Barnes, the BAU meets in secret to investigate an UnSub who appears to be kidnapping and photographing young women.

The BAU is called to Oklahoma to investigate a murderous clown terrorizing the sleepy town of Guymon.

The BAU travels to Chicago to investigate an unsub who leaves red roses on each victim. Also, Rossi gets an unexpected visit from his ex-wife, Krystall Richards.

The BAU takes charge of a hostage situation at a law firm in D.C., where Matt Simmons’ wife, Kristy works.

The BAU is called to investigate a series of deaths in Virginia suspected by the Center for Disease Control to be caused by bio-terrorism; Garcia visits her stepbrother to take care of a family issue.

The BAU is called to Taos, N.M. to investigate an UnSub who is targeting his victims' temporal lobes.

When Reid discovers former FBI Special Agent Owen Quinn locked inside a storage unit, the BAU questions the credibility of Quinn's bizarre accounts of searching for an UnSub that he named "The Strangler".