Steve Carell

Gru (voice)

Kristen Wiig

Agent Lucy Wilde (voice)

Benjamin Bratt

Eduardo 'El Macho' Pérez (voice)

Miranda Cosgrove

Margo (voice)

Russell Brand

Dr. Nefario (voice)

Ken Jeong

Floyd Eagle-san (voice)

Steve Coogan

Silas Ramsbottom (voice)

Elsie Fisher

Agnes (voice)

Dana Gaier

Edith (voice)

Moisés Arias

Antonio Pérez (voice)

Nasim Pedrad

Jillian (voice)

Kristen Schaal

Shannon (voice)

Pierre Coffin

Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice)

Chris Renaud

Additional Minions / Evil Minions / Italian Waiter (voice)

Nickolai Stoilov

Arctic Lab Guards (voice)

Vanessa Bayer

Flight Attendant (voice)

Ava Acres

Additional Voices (voice)

Lori Alan

Additional Voices (voice)

Jack Angel

Additional Voices (voice)

Eva Bella

Additional Voices (voice)

Georgia Cook

Additional Voices (voice)

John Cygan

Additional Voices (voice)

Debi Derryberry

Additional Voices (voice)

Jess Harnell

Additional Voices (voice)

Danny Mann

Additional Voices (voice)

Mona Marshall

Additional Voices (voice)

Mickie McGowan

Additional Voices (voice)

Mason McNulty

Additional Voices (voice)

Alec Medlock

Additional Voices (voice)

Laraine Newman

Additional Voices (voice)

Jan Rabson

Additional Voices (voice)

Andre Robinson

Additional Voices (voice)

Katie Silverman

Additional Voices (voice)

Casey Simpson

Additional Voices (voice)

Claira Nicole Titman

Additional Voices (voice)

Jim Ward

Additional Voices (voice)

April Winchell

Additional Voices (voice)

Joe Matthews

Additional Voices (voice)

Aria Noelle Curzon

(uncredited)

Audrey Lamy

Agent Lucy Wilde (French Voice)